During last few years mucoadhesive dosage forms have promoted an area of drug delivery system that renders the treatment more effective and safe, not only for topical disorders but also for systemic problems. Bioadhesive formulations have a wide scope of application for both systemic and local effects of drugs. Timolol maleate is a non-selective beta-adrenergic blocker, and having short biological half-life, approximate 4.1 h, and low oral bioavailability.The aim of the present study was to design formulation and evaluate the mucoadhesive buccal patches containing the timolol maleate drug using the different ratios of hydrophilic polymers like carbopol 934P, PVA, PVP by using the solvent casting technique.The patches which were prepared by the solvent casting method, were smooth and elegant in appearance. prepared films were evaluated for weight, thickness, surface pH ,swelling index(SI), folding endurance, drug content uniformity, in vitro drug realese studies.Thermal analysis by DSC show no intreaction between drug and polymers. In vitro drug release studies were performed using USP apparatus-II at 50 rpm.A faster drug release rate was observed for patches prepared with the low concentration of PVPK30. It was also observed that patches prepared with high concentration of PVP K30 show highest swelling index and increasing concentration of PVA shows high tensile strength of mucoadhesive patches.kinetic study mainly revealed that the drug releases from the patches follow zero order kinetics.
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